Solid-state nanopore fabrication by automated controlled breakdown.

Matthew Waugh, Kyle Briggs, Dylan Gunn, Mathieu Gibeault, Simon King, Quinn Ingram, Aura Melissa Jimenez, Samuel Berryman, Dmytro Lomovtsev, Lukasz Andrzejewski and Vincent Tabard-Cossa

Nature Protocols – read

See also Press Release in EN and FR

Programmable DNA Nanoswitch Sensing with Solid-State Nanopores

Eric Beamish, Vincent Tabard-Cossa, Michel Godin.

ACS Sensors (2019). 4(9): 2458-2464. – read

Fast capture and multiplexed detection of short multi-arm DNA stars in solid-state nanopores

Liqun He, Philipp Karau, Vincent Tabard-Cossa

Nanoscale. 11(35): 16342-16350. – read

Precise DNA Concentration Measurements with Nanopores by Controlled Counting

Martin Charron, Kyle Briggs, Simon King, Matthew Waugh, Vincent Tabard-Cossa.

Analytical Chemistry. 91(19): 12228-12237. – read

Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis

Thebault S, Abdoli M, Fereshtehnejad SM, Tessier D Tabard-Cossa V, Freedman MS


Monolithic Fabrication of NPN/SiNx Dual Membrane Cavity for Nanopore-Based DNA Sensing

Gregory R Madejski, Kyle Briggs, Jon-Paul DesOrmeaux, Joshua J Miller, James A Roussie, Vincent Tabard-Cossa, James L McGrath

Advanced Materials Interfaces. 6(14): 1900684. – read

Effect of flow on nanopore sensor performance when confined in a microchannel.

Ali Najafi Sohi, Eric Beamish, Vincent Tabard-Cossa, and Michel Godin


Entropic Trapping of DNA with a Nanofiltered Nanopore

Michelle H Lam, Kyle Briggs, Konstantinos Kastritis, Martin Magill, Gregory R Madejski, James L McGrath, Hendrick W de Haan, Vincent Tabard-Cossa

ACS Applied Nano Materials. 23(8): 4773-4781. – read

Digital counting of microRNA using solidstate nanopores.

Eric Beamish, Vincent Tabard-Cossa and Michel Godin


High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS.

Simon Thebault, Daniel R Tessier, Hyunwoo Lee, Marjorie Bowman, Amit Bar-Or, Douglas L Arnold, Harold L Atkins, Vincent Tabard-Cossa, Mark S Freedman

Neurology-Neuroimmunology Neuroinflammation. 6(5): e598. – read

Blood biomarkers of neurotoxicity following Autologous Haematopoetic Stem Cell Transplantation for multiple sclerosis

Thebault S, Lee H, Tessier D, Bose G Bowman M, Bar-Or A, Arnold D, Atkins H, Tabard-Cossa V. Freedman MS



DNA Translocations Through Nanopores Under Nanoscale Pre-Confinement.

Briggs, K.; Madejski, G.; Magill, M.; Kastritis, K.; de Haan, H.W.; McGrath, J.L. Tabard-Cossa, V.

Nano Letters (on the cover). 18(2): 660-668. – read

Press Release
Media Coverage
Below: A video, by co-author G. Madejski, describing the operation of the nanofiltered nanopore device

Instrumentation for Low Noise Nanopore-based Ionic Current Recording under Laser Illumination

Roelen, R.; Bustamante, A. J.; Carlsen, A.; Baker-Murray, A.; Tabard-Cossa, V.

Review of Scientific Instruments. 89(1): 015007. – read

Capture and Translocation Characteristics of Short Branched DNA Labels in Solid-State Nanopores

Karau, P.; Tabard-Cossa, V.

ACS Sensors. 3(7): 1308-1315. – read


Solid-state nanopore localization by controlled breakdown of selectively thinned membranes

Carlsen, A. T.; Briggs, K.; Hall, A. R.; Tabard-Cossa, V

Nanotechnology. 28: 085304. – read

Manipulating Electrical and Fluidic Access in Integrated Nanopore-Microfluidic Arrays Using Microvalves

Tahvildari, R.; Beamish, E.; Briggs, K.; Chagnon-Lessard, S.; Najafi Sohi, A.; Han, S.; Watts, B.; TabardCossa, V.; Godin, M

Small. 13: 1602601. – read

Identifying Structure in short DNA scaffolds using solidstate nanopores

Beamish, E.; Tabard-Cossa, V.; Godin, M

ACS Sensors. 2(12): 1814–1820. – read

Nanopores: electronic tools for single-molecule biophysics and bio-nanotechnologies

Tabard-Cossa, V.; Briggs, K.; Carlsen, A.; Charron, M.; Karau, P.; Roelen, Z.; Waugh, M

Physics in Canada. 73(2)


Portable cytometry using microscale electronic sensing

Emaminejad, S.; Paik, K.; Tabard-Cossa, V.; Javanmard, M

Sensors and Actuators B: Chemical. 224: 275-281. – read

MOSAIC: A Modular Single Molecule Analysis Interface for Decoding Multi-state Nanopore Data

Forstater, J.H.; Briggs, K.; Robertson, J.WF.; Ettedgui, J.; Marie-Rose, O.; Vaz, C.; Kasianowicz, J.J.; Tabard-Cossa, V.; Balijepalli, A

Analytical Chemistry. 88(23): 11900-11907. – read

Nanopore-based target sequence detection

Morin, Trevor; Shropshire, Tyler; Liu, Xu; Briggs, Kyle; Huynh, Cindy; Tabard-Cossa, Vincent; Wang, Hongyun; Dunbar, William

PLoS ONE. 11(5): e0154426. – read


Kinetics of nanopore fabrication during controlled breakdown of dielectric membranes in solution

Briggs, Kyle; Charron, Martin; Kwok, Harold; Le, Timothea; Chahal, Sanmeet; Bustamante, José; Waugh, Matthew; Tabard-Cossa, Vincent

Nanotechnology. 26(8): 084004. – read

Integrating nanopore sensors within microfluidic channel arrays using controlled breakdown

Tahvildari, Radin; Beamish, Eric; Tabard-Cossa, Vincent; Godin, Michel

Lab on a Chip. 15(6): 1407-1411. – read

Interfacing Solid-State Nanopores with Gel Media to Slow DNA Translocations

Waugh, Matthew; Carlsen, Autumn; Sean, David; Slater, Gary; Briggs, Kyle; Kwok, Harold; and TabardCossa, Vincent

Electrophoresis, 36: 1759-1767. – read


Long Passage Times of Short ssDNA Molecules through Metallized Nanopores Fabricated by Controlled Breakdown

Kwok, Harold; Waugh, Matthew; Bustamante, José; Briggs, Kyle; Tabard-Cossa, Vincent

Advanced Functional Materials. 24(48): 7745-7753. – read

Nanopore Fabrication by Controlled Dielectric Breakdown

Kwok, Harold; Briggs, Kyle; Tabard-Cossa, Vincent

PLoS ONE. 9(3): e92880. – read

In the news

Automated Fabrication of 2-nm Solid-State Nanopores for Nucleic Acid Analysis

Briggs, Kyle; Kwok, Harold; Tabard-Cossa, Vincent

Small. 10(10): 2077-2086. – read

In the news:
Read the in Sequence Genomeweb story here or download a pdf.
Read the Advanced Science News here


Fine-Tuning the Size and Minimizing the Noise of Solid-State Nanopores

Beamish, Eric; Kwok, Harold; Tabard-Cossa, Vincent; Godin, Michel

Journal of Visualized Experiments. 80: e51081. – read

Chapter 3: Instrumentation for Low-Noise High-Bandwidth Nanopore Recording

Tabard-Cossa, V

Edel, J. (Imperial College London) B. and Albrecht, T. (University of Birmingham). Engineered Nanopores for Bioanalytical Applications. : 59-88. – read


Precise control of the size and noise of solid-state nanopores using high electric fields

Beamish, E.; Kwok, H.; Tabard-Cossa, V.; and Godin, M

Nanotechnology 23, 405301, 7 pages. – read

Control of DNA Capture by Nanofluidic Transistors

Paik, K. H.; Liu, Y.; Tabard-Cossa, V.; Waugh, M. J.; Huber, D. E.; Provine, J; Howe, R. T.; Dutton, R. W.; and Davis, R. W.

ACS Nano 6, 6767–6775 (2012). – read

Pre-uOttawa Publications
  • Jetha N. N., Feehan C., Wiggin M., Tabard-Cossa V., Marziali A., “Long Dwell-Time Passage of DNA through Nanometer-Scale Pores: Kinetics and Sequence Dependence of Motion” Biophysical Journal 100, 2974-2980 (2011) – read
  • Paik, K. H.; Liu, Y.; Tabard-Cossa, V.; Huber, D. E.; Provine, J.; Howe, R. T.; Dutton, R. W.; Davis, R. W. “Efficient Control of DNA Motion and Translocation in Nanopore-based Nanofluidic Transistors” 15th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2011) Seattle, USA, (2011) –
  • Paik, K. H.; Liu, Y.; Tabard-Cossa, V.; Huber, D. E.; Provine, J.; Howe, R. T.; Dutton, R. W.; Davis, R. W. “Experimental Demonstration and Analysis of DNA Passage in Nanopore-based Nanofluidic Transistors” IEEE International Electron Devices Meeting (IEDM), Washington, USA (2011)
  • Liu Y., Huber D., Tabard-Cossa V., Dutton R. W., “Descreening of field effect in electrically gated nanopores” Applied Physics Letters 97, 143109 (2010) – read
  • Godin M.*, Tabard-Cossa V.*, Miyahara Y., Monga T., Williams P J, Beaulieu L Y, Lennox R B., Grutter P., “Cantilever-Based Sensing: Origin of the Surface Stress and Optimization Strategies”. Nanotechnology 21, 075501 (2010) *These authors contributed equally to this work – read


  • Tabard-Cossa V., Wiggin M., Trivedi D., Jetha N. N., Dwyer J. R., Marziali A., “Single-Molecule Bonds Characterized by Solid-State Nanopore Force Spectroscopy” ACS Nano 3 (10), 3009-3014 (2009) – read


  • Branton D., Deamer W .D., Marziali A., … , Tabard-Cossa V. et al.; “The potential and challenges of nanopore sequencing” Nature Biotechnology 26, 1146-1153 (2008) – read
  • Wiggin M.; Tropini C.; Tabard-Cossa V.; and Marziali A.; “Non-exponential kinetics of DNA escape from alpha-Hemolysin nanopores” Biophysical Journal 95, 5317–5323 (2008) – read


  • Tabard-Cossa, V.; Godin, M.; Burgess, I.; Monga, T.; Lennox, R. B.; Grütter, P.; “Microcantilever-based Sensors: Effect of Morphology, Adhesion and Cleanliness of the Sensing Substrate on Surface Stress” Analytical Chemistry 79, 8136 -8143, (2007) – read
  • Tabard-Cossa, V.; Trivedi, D.; Wiggin, M.; Jetha, N.; Marziali, A.; “Noise Analysis and Reduction in Solid-State Nanopores” Nanotechnology 18, 305505 (2007) – read
  • Beaulieu L.Y. ; Godin M.; Laroche O.; Tabard-Cossa V.; and Peter Grütter, “A complete analysis of the laser beam deflection systems used in cantilever-based systems” Ultramicroscopy 107, 422-430 (2007) – read


  • Beaulieu, L.Y.; Godin, M.; Laroche, O.; Tabard-Cossa, V.; Grütter, P.; “Calibrating Laser Beam Deflection Systems for use in Atomic Force Microscopes and Cantilever Sensors” Applied Physics Letters 88, 083108 (2006) – read


  • Tabard-Cossa, V.; Godin, M.; Burgess, I.; Lennox, R. B.; Grütter, P.; “Redox-induced Surface Stress of Polypyrrole-based actuators” Journal of Physical Chemistry B 109 (37), 17531-17537 (2005) – read
  • Tabard-Cossa, V.; Godin, M.; Beaulieu, L.Y.; Grütter, P.; “A Differential Microcantilever-Based System for Measuring Surface Stress Changes Induced by Electrochemical Reactions” Sensors and Actuators B 107, 233-241 (2005) – read – Erratum: Sensors and Actuators B 119, 352-354 (2006) – read


  • Godin, M.; Williams, P.J.; Tabard-Cossa, V.; Laroche, O.; Beaulieu, L.Y.; Lennox, R. B.; Grütter, P.; “Surface Stress, Kinetics, and Structure of Alkanethiol Self-Assembled Monolayers” Langmuir 20, 7090 (2004) – Featured on the Langmuir journal coverread


  • Quist, F.; Tabard-Cossa, V.; Badia, A. “Nanomechanical Cantilever Motion Generated by a Surface-Confined Redox Reaction” Journal of Physical Chemistry B 107, 10691-10695 (2003) – read
  • Godin, M.; Laroche, O.; Tabard-Cossa, V.; Beaulieu, L.Y.; Grütter, P.; Williams, P.J.; “Combined in situ Micromechanical Cantilever-Based Sensing and Ellipsometry” Review of Scientific Instruments 74, 4902 (2003) – read


  • Godin, M.; Tabard-Cossa, V.; Grütter, P.; Williams, P.; “Quantitative Surface Stress Measurements using a Microcantilever” Applied Physics Letter 79, 551 (2001) – read

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