Applied Single-Molecule Biophysics

The T.-Cossa LAB is located in the Center for Interdisciplinary Nanophysics, in the Department of Physics at the University of Ottawa

Our research is dedicated to the development of novel techniques and methods to manipulate and characterize single-molecules using nanofluidic devices, to unravel the basic physics governing the behaviour of biological molecules in nanoconfined geometries, and ultimately to translate these discoveries into new tools for the life sciences.

While our research efforts are driven by the exploration of unique detection and actuation modalities, the manipulation and characterization of individual molecules within nanoscale fluidic environments (i) represents an important and largely uncharted regime in which interesting new physics can dominate and (ii) enables new quantitative measurements, with exceptional sensitivity and speed, on the structure and behavior of biological molecules.

The T.-Cossa Laboratory offers a multidisciplinary research environment. Our research relies on nanodevice fabrication and on the design of custom instrumentation. We employ low-noise current amplifiers for single-molecule electrical detection and fluorescence microscopy for optical tracking of individual biomolecules. Visit the research page to learn more about our current research projects.


A protein bound to a dsDNA molecule. The molecular complex is threaded through a sub-5 nm solid-state nanopore to unravel DNA-protein interactions or the local protein structure for gene regulation studies.

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